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PEGylated DOX-coated nano graphene oxide as pH-responsive multifunctional nanocarrier for targeted drug delivery

期刊: JOURNAL OF DRUG TARGETING, 2021; 29 (8)

Nano graphene oxide (NGO) has high drug-loading capacity due to its huge surface area. However, the limited stability and the poor biocompatibility of......

Targeting PRAS40: a novel therapeutic strategy for human diseases

期刊: JOURNAL OF DRUG TARGETING, 2021; 29 (7)

Proline-rich Akt substrate of 40 kD (PRAS40) is not only the substrate of protein kinase B (PKB/Akt), but also the binding protein of 14-3-3 protein. ......

Silencing long non-coding RNA HNF1A-AS1 inhibits growth and resistance to TAM of breast cancer cells via the microRNA-363/SERTAD3 axis

期刊: JOURNAL OF DRUG TARGETING, 2021; 29 (7)

Long non-coding RNAs (lncRNAs) can exert effects on drug resistance of cancer cells. This study investigated the role of lncRNA HNF1A-antisense 1 (HNF......

RETRACTED ARTICLE: Melanin-based biomimic photothermal nanoparticles for therapeutic application in diabetic nephropathy

期刊: JOURNAL OF DRUG TARGETING, 2021; 29 (5)

We, the authors, Editors and Publisher of the Journal of Drug Targeting have retracted the following article: Wen Lu, Gongqi Chen & Wenfang Li, Me......

Delivery of RGD-modified liposome as a targeted colorectal carcinoma therapy and its autophagy mechanism

期刊: JOURNAL OF DRUG TARGETING, ; ()

Liposomes are among the most extensively applied drug carriers due to their excellent biocompatibility, controllable size and ease of modification. In......

MicroRNA-185 activates PI3K/AKT signalling pathway to alleviate dopaminergic neuron damage via targeting IGF1 in Parkinson's disease

期刊: JOURNAL OF DRUG TARGETING, ; ()

Objectives Studies have extensively explored the role of microRNAs (miRs) in Parkinson's disease (PD) and miR-185 is related to autophagy and apoptosi......

Pressure-driven accumulation of Mn-doped mesoporous silica nanoparticles containing 5-aza-2-deoxycytidine and docetaxel at tumours with a dry cupping device

期刊: JOURNAL OF DRUG TARGETING, ; ()

Drug delivery with the help of nanoparticles could transport more payloads to tumour site. Owing to their limited accumulation and penetration in the ......

Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway

期刊: JOURNAL OF DRUG TARGETING, ; ()

Metformin has been shown to protect myocardial ischaemia/reperfusion or hypoxia/reoxygenation injury. In our current study, we investigated the effect......

Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer's disease in rats via the Rho/ROCK signalling pathway

期刊: JOURNAL OF DRUG TARGETING, ; ()

Objective: It is believed that microRNAs (miRNAs) participate in the pathogenesis of Alzheimer's disease (AD), but the specified function of miR-10b-5......

New designed pH-responsive histidine-rich peptides with antitumor activity

期刊: JOURNAL OF DRUG TARGETING, ; ()

Anticancer peptides have received widespread attention as alternative antitumor therapeutics due to their unique action mode. However, the systemic to......

The relevant targets of anti-oxidative stress: a review

期刊: JOURNAL OF DRUG TARGETING, ; ()

Previous studies have found that oxidative stress is the negative reaction of the imbalance between oxidation and antioxidation caused by free radical......

A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances

期刊: JOURNAL OF DRUG TARGETING, ; ()

Posterior segment eye disease is a leading cause of irreversible vision impairment and blindness. As the unique organ for vision, eyes are protected b......

Promoting plaque stability by gene silencing of monocyte chemotactic protein-3 or overexpression of tissue factor pathway inhibitor in ApoE-/- mice

期刊: JOURNAL OF DRUG TARGETING, ; ()

Chemokines may promote the formation and instability of atherosclerotic plaque, which is the most common cause of acute coronary syndrome. The aim of ......

Histone deacetylase 9 inhibition upregulates microRNA-92a to repress the progression of intracranial aneurysm via silencing Bcl-2-like protein 11

期刊: JOURNAL OF DRUG TARGETING, ; ()

Objective Histone deacetylases (HDACs) have been revealed to be involved in cerebrovascular diseases, while the role of HDAC9 in intracranial aneurysm......

TIGIT/PVR and LncRNA ANRIL dual-targetable PAMAM polymeric nanoparticles efficiently inhibited the hepatoma carcinoma by combination of immunotherapy and gene therapy

期刊: JOURNAL OF DRUG TARGETING, ; ()

Herein, a novel polymeric nanoparticle was designed to inhibit hepatoma carcinoma by simultaneously targeting the T cell immunoreceptor with Ig and IT......

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