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Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects

期刊: DRUG DELIVERY, 2021; 28 (1)

Melanoma is one of the most common malignant tumors. The anti-PD-1 antibody is used for the treatment of metastatic melanoma. Treatment success is onl......

Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles

期刊: DRUG DELIVERY, 2021; 28 (1)

Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which i......

Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage

期刊: DRUG DELIVERY, 2021; 28 (1)

In the human body, joint cartilage is of great importance. It has long been a big therapeutic problem to fix joint cartilage lesions as it appears due......

Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer

期刊: DRUG DELIVERY, 2021; 28 (1)

A novel gold nanoparticle (Do-AuNP) was successfully synthesized from water extracts of traditional Chinese medicine Dendrobium officinale (DO) withou......

Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

期刊: DRUG DELIVERY, 2021; 28 (1)

Glucocorticoid (GC) hormone has been commonly used to treat systemic inflammation and immune disorders. However, the side effects associated with long......

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

期刊: DRUG DELIVERY, 2021; 28 (1)

The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the ......

Rational formulation engineering of fraxinellone utilizing 6-O-alpha-D-maltosyl-beta-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

期刊: DRUG DELIVERY, 2021; 28 (1)

Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered......

Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro

期刊: DRUG DELIVERY, 2021; 28 (1)

Chemotherapy plays a major role in the treatment of cancer, but it still has great limitations in anti-tumor effect. Carboplatin (CAR) is the first-li......

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

期刊: DRUG DELIVERY, 2021; 28 (1)

Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2......

Layer-by-Layer assembled nano-drug delivery systems for cancer treatment

期刊: DRUG DELIVERY, 2021; 28 (1)

Nano-drug delivery systems (NDDS) are functional drug-loaded nanocarriers widely applied in cancer therapy. Recently, layer-by-layer (LbL) assembled N......

Engineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy

期刊: DRUG DELIVERY, 2021; 28 (1)

Chemotherapy with combination drugs has become one of the most commonly used cancer prevention treatments, with positive clinical results. The goal of......

A novel dendritic mesoporous silica based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced inflammation in rats

期刊: DRUG DELIVERY, 2021; 28 (1)

Purpose S-propargyl-cysteine (SPRC), an excellent endogenous hydrogen sulfide (H2S) donor, could elevate H2S levels via the cystathionine gamma-lyase ......

Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone

期刊: DRUG DELIVERY, 2021; 28 (1)

Prostate cancer is the second most frequently diagnosed cancer in the men population. Combination anticancer therapy using doxorubicin (DOX) and anoth......

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

期刊: DRUG DELIVERY, 2021; 28 (1)

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through......

Experimental anti-tumor effect of emodin in suspension - in situ hydrogels formed with self-assembling peptide

期刊: DRUG DELIVERY, 2021; 28 (1)

Lung cancer is a major cause of cancer-related deaths worldwide. Stimulus-sensitive hydrogels, which can be formed by responding to stimuli in the can......

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