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Rational formulation engineering of fraxinellone utilizing 6-O-alpha-D-maltosyl-beta-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

Li, JB; Feng, TG; Yang, WJ; Xu, YR; Wang, SS; Cai, HJ; Liu, ZL; Qiang, H; Zhang, JJ

Zhang, JJ (corresponding author), 100 Kexue Rd, Zhengzhou 450001, Henan, Peoples R China.

DRUG DELIVERY, 2021; 28 (1): 1890

Abstract

Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered......

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