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Astrocytic IP(3)Rs: Beyond IP(3)R2

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate neuronal functions (synaptic transmission, synaptic plastic......

Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hy......

Oxytocin Regulates Synaptic Transmission in the Sensory Cortices in a Developmentally Dynamic Manner

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

The development and stabilization of neuronal circuits are critical to proper brain function. Synapses are the building blocks of neural circuits. Her......

Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca2+ homeostasis. The stress respons......

Retinal Organoids: Cultivation, Differentiation, and Transplantation

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Retinal organoids (ROs), which are derived from stem cells, can automatically form three-dimensional laminar structures that include all cell types an......

Astrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Reactive astrogliosis is a key hallmark of inflammatory responses in the pathogenesis of brain injury, including Parkinson's disease (PD), but its rol......

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective t......

A Temporal Activity of CA1 Neurons Underlying Short-Term Memory for Social Recognition Altered in PTEN Mouse Models of Autism Spectrum Disorder

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Memory-guided social recognition identifies someone from previous encounters or experiences, but the mechanisms of social memory remain unclear. Here,......

Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Myelin abnormalities have been observed in autism spectrum disorder (ASD). In this study, we seek to discover myelin-related changes in the striatum, ......

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN). ID......

The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's Disease

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative disorders worldwide and poses a major challenge for both affected i......

MiR-30c-5p/ATG5 Axis Regulates the Progression of Parkinson's Disease

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Serum miR-30c-5p correlates with Parkinson's disease (PD), yet its role has not been illustrated. This research analyzed the function of miR-30c-5p in......

Analysis of Hemichannels and Gap Junctions: Application and Extension of the Passive Transmembrane Ion Transport Model

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three ge......

Astrocytic IP(3)Rs: Beyond IP(3)R2

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Y Astrocytes are sensitive to ongoing neuronal/network activities and, accordingly, regulate neuronal functions (synaptic transmission, synaptic plast......

Cerebral Edema Formation After Stroke: Emphasis on Blood-Brain Barrier and the Lymphatic Drainage System of the Brain

期刊: FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ()

Brain edema is a severe stroke complication that is associated with prolonged hospitalization and poor outcomes. Swollen tissues in the brain compromi......

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