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Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

Deng, N; Hu, J; Hong, Y; Ding, YW; Xiong, YF; Wu, ZY; Xie, W

Xie, W (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.; Xie, W (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Tradit Chinese Med, Guangzhou, Peoples R China.

FRONTIERS IN CELLULAR NEUROSCIENCE, 2021; 15 ():

Abstract

Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN). ID......

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