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Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 198 ()

In this study, the multiple fingerprints, which were integrated with HPGFC-ELSD (high performance gel filtration chromatography - evaporative light sc......

Development of a rapid and sensitive UPLC-MS/MS assay for simultaneous quantitation of Vorolanib and its metabolite in human plasma and application to a pharmacokinetics study

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 199 ()

Vorolanib is an oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor rec......

Quantification and discovery of quality control chemical markers for Ba-Bao-Dan by UPLC-MS/MS combined with chemometrics

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 204 ()

Ba-Bao-Dan (BBD) is a well-known Traditional Chinese medicine (TCM) prescription in China. It was first formulated in approximately 1555 AD. As one of......

Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 198 ()

Xin-Nao-Kang Capsule (XNKC), a well-known traditional Chinese medicine (TCM), is widely used for the treatment of angina pectoris, cerebral arterioscl......

Investigation of the therapeutic effect of Yinchen Wuling Powder on CCl4-induced hepatic fibrosis in rats by H-1 NMR and MS-based metabolomics analysis

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 200 ()

Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling P......

Integrating multiple-chromatographic approaches to evaluate chemical consistency of Chang-Kang-Fang preparations from mixed-herb decoction and combined single-herb decoction

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 203 ()

Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription for treating irritable bowel syndrome (IBS), has been cli......

The synergistic anti-depression effects of different efficacy groups of Xiaoyaosan as demonstrated by the integration of network pharmacology and serum metabolomics

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 197 ()

Compatibility investigations are vital but also the most difficult aspect of traditional Chinese medicine (TCM) prescriptions. Previous researches hav......

High stability amino-derived reversed-phase/anion-exchange mixed-mode phase based on polysilsesquioxane microspheres for simultaneous separation of compound drugs

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 203 ()

A series of amino-derived mixed-mode chromatographic stationary phases were synthesized based on porous mercaptopropyl-functionalized polysilsesquioxa......

Simultaneous quantification of twenty-eight components of Shenfu Injection in rat plasma by UHPLC-QQQ MS and its application to a pharmacokinetic study

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 203 ()

Shenfu Injection (SFI), derived from the classical traditional Chinese medicine formula "Shenfu Decoction", is a modern preparation used to treat hear......

A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 199 ()

Berberine (BBR), isolated from Coptis chinensis, is one type of isoquinoline alkaloids. BBR exerts numerous of bioactivities but the plasma concentrat......

Authentication of Hedyotis products by adaptor ligation-mediated PCR and metabarcoding

期刊: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021; 196 ()

DNA barcoding is a widely used tool for species identification and authentication. However, it may not be applicable to highly processed herbal produc......

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