期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (4)
Sample multiplexing facilitates single-cell sequencing by reducing costs, revealing subtle difference between similar samples, and identifying artifac......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (6)
Transposable elements (TEs) are widespread across eukaryotic genomes, yet their content varies widely between different species. Factors shaping the d......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (8)
Understanding the mechanism of SARS-CoV-2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharma......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (4)
Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell-cell and......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (4)
Elucidating the chromatin dynamics that orchestrate embryogenesis is a fundamental question in developmental biology. Here, we exploit position effect......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2021; 17 (2)
Reproducibility of scientific results is a key element of science and credibility. The lack of reproducibility across many scientific fields has emerg......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (5)
Recent studies have revealed that global extrinsic noise arising from stochasticity in the intracellular biochemical environment plays a critical role......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (11)
Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m(6)A and m(5)C, have been associated w......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (3)
Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function. T......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (4)
The prevalence of non-alcoholic fatty liver disease (NAFLD) continues to increase dramatically, and there is no approved medication for its treatment.......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (4)
Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. ......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2019; 15 (7)
In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day-night cycle. Failure of synchrony, which inc......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2017; 13 (10)
The postantibiotic effect (PAE) refers to the temporary suppression of bacterial growth following transient antibiotic treatment. This effect has been......
期刊: MOLECULAR SYSTEMS BIOLOGY, 2022; 18 (9)
Current strategies to improve the throughput of continuous directed evolution technologies often involve complex mechanical fluid-controlling system o......