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Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy

Kim, DW; Chang, C; Chen, X; Doran, AC; Gaudreault, F; Wager, T; DeMarco, GJ; Kim, JK

Kim, JK (reprint author), Korea Adv Inst Sci & Technol, Dept Math Sci, Daejeon, South Korea.; Chang, C (reprint author), Pfizer Inc, Clin Pharmacol, Pfizer Global Prod Dev, Groton, CT 06340 USA.

MOLECULAR SYSTEMS BIOLOGY, 2019; 15 (7):

Abstract

In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day-night cycle. Failure of synchrony, which inc......

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