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Safety, Pharmacokinetics and Pharmacodynamics of Multiple Escalating Doses of PEGylated Exenatide (PB-119) in Healthy Volunteers

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2021; 46 (2)

Background and Objective At present, the deficiency of beta-cell function is progressive in patients with type 2 diabetes mellitus. Exenatide cannot o......

Serum and Synovial Vancomycin Concentrations in Patients with Prosthetic Joint Infection after Intra-articular Infusion

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2021; 46 (5)

Background and Objectives Vancomycin is one of the most commonly used antibiotics for intra-articular (IA) infusion in the treatment of prosthetic joi......

Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, ; ()

Background and Objective Eltrombopag is the first oral, small-molecule, non-peptide thrombopoietin receptor agonist for the treatment of idiopathic th......

The Impact of Smoking, Sex, Infection, and Comedication Administration on Oral Olanzapine: A Population Pharmacokinetic Model in Chinese Psychiatric Patients

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, ; ()

Plain Language Summary This study included a total of 1546 serum olanzapine concentrations from 354 Chinese adult psychiatric patients that were analy......

The Pharmacokinetics and Tissue Distributions of Nine Steroidal Saponins fromParis polyphyllain Rats

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (5)

Background and Objectives Paris polyphylla(P. polyphylla) is a herb widely used in traditional Chinese medicine to treat various diseases. This study ......

A Population Pharmacokinetics Model for Vancomycin Dosage Optimization Based on Serum Cystatin C

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (4)

Background and Objectives Renal function has an important influence on the pharmacokinetics of vancomycin, and serum cystatin C (CysC) exhibits accura......

Population Pharmacokinetic Analysis of Tacrolimus in Adult Chinese Patients with Myasthenia Gravis: A Prospective Study

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (4)

Background and Objectives Tacrolimus is a widely used immunosuppressive agent with narrow therapeutic window. Nowadays, tacrolimus has gained acceptan......

Pharmacokinetics of Polyethylene Glycol-Modified Canine Uricase Following Single and Multiple Intravenous Injections in Cynomolgus Monkeys

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (4)

Background and Objective Polyethylene glycol-modified canine uricase (PEG-UHC) prepared with a lower-molecular-weight (5 kDa) PEG is used to treat gou......

UFLC-MS/MS Determination and Population Pharmacokinetic Study of Tanshinol, Ginsenoside Rb1 and Rg1 in Rat Plasma After Oral Administration of Compound Danshen Dripping Pills

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (4)

Background and Objectives As a traditional Chinese Materia Medica (CMM), the Compound Danshen Dripping Pill (CDDP) is widely used for the treatments o......

Safety, Tolerability and Pharmacokinetics of Single Dose Polyethylene Glycolated Exenatide Injection (PB-119) in Healthy Volunteers

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (3)

Background and Objective Exenatide promotes insulin secretion and inhibits postprandial glucagon secretion. Polyethylene glycolated exenatide injectio......

Comparison of the Predictive Performance Between Cystatin C and Serum Creatinine by Vancomycin via a Population Pharmacokinetic Models: A Prospective Study in a Chinese Population

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (1)

Background Most of the current published population pharmacokinetic (PopPK) models are based on serum creatinine, but we often encounter an underestim......

The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (1)

Background SPH3127 is a novel direct renin inhibitor designed as an oral drug for the regulation of blood pressure and body fluid homeostasis via the ......

Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020; 45 (4)

Background and Objectives Driving under the influence of diazepam is increasing in China. The pharmacokinetics of diazepam and its metabolites, especi......

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