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Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats

Xie, ZL; Chen, M; Goswami, S; Mani, R; Wang, DS; Kulp, SK; Coss, CC; Schaaf, LJ; Cui, FY; Byrd, JC; Jennings, RN; Schober, KK; Freed, C; Lewis, S; Malbrue, R; Muthusamy, N; Bennett, C; Kisseberth, WC; Phelps, MA

Phelps, MA (corresponding author), Ohio State Univ, Coll Pharm, Div Pharmaceut & Pharmacol, 506 Riffe Bldg,496 W 12th Ave, Columbus, OH 43210 USA.; Kisseberth, WC (corresponding author), Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.; Phelps, MA (corresponding author), Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA.; Kisseberth, WC (corresponding author), Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, 448 VMAB,1900 Coffey Rd, Columbus, OH 43210 USA.

AAPS JOURNAL, 2020; 22 (4):

Abstract

In this study, we characterized the pharmacokinetics of OSU-2S, a fingolimod-derived, non-immunosuppressive phosphatase activator, in mice, rats, and ......

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