期刊： AAPS JOURNAL, 2021; 23 (2)
Pancreatic cancer is a highly malignant tumor and one of the primary causes of cancer-related death. Because pancreatic cancer is difficult to diagnos......
期刊： AAPS JOURNAL, 2021; 23 (3)
Dry powder inhaler (DPI) is recognized as the first choice for lung diseases' treatment. However, it lacks a universal way for DPI formulation develop......
期刊： AAPS JOURNAL, 2021; 23 (3)
In the absence of regulatory guidelines for the bioanalysis of new drug modalities, many of which contain multiple functional domains, bioanalytical s......
期刊： AAPS JOURNAL, 2021; 23 (4)
3D printing has emerged as an advanced manufacturing technology in the field of pharmaceutical sciences. Despite much focus on enteral applications, t......
期刊： AAPS JOURNAL, 2021; 23 (2)
As one of the most important metabolites of vitamin A, all-trans retinoic acid (RA) plays a crucial role in regulating immune responses. RA has been s......
期刊： AAPS JOURNAL, 2021; 23 (2)
Bioequivalence (BE) is usually hard to achieve for extended-release (ER) dosage form products due to not only its complicated formulation but also to ......
期刊： AAPS JOURNAL, 2021; 23 (3)
In the context of streamlining generic approval, this study assessed whether pharmacokinetics (PK) could elucidate the pulmonary fate of orally inhale......
期刊： AAPS JOURNAL, 2020; 22 (5)
Intraperitoneal chemoperfusion (IPEC) of cisplatin is a popular treatment for advanced ovarian cancer, typically under hyperthermia (HIPEC). The use o......
期刊： AAPS JOURNAL, 2020; 22 (2)
Immuno-PET is a molecular imaging technique utilizing positron emission tomography (PET) to measure the biodistribution of an antibody species labeled......
期刊： AAPS JOURNAL, 2020; 22 (2)
This study aimed to develop a method for implementing dose correction in a Michaelis-Menten (M-M) approximation of a target-mediated drug disposition ......
期刊： AAPS JOURNAL, 2020; 22 (4)
In this study, we characterized the pharmacokinetics of OSU-2S, a fingolimod-derived, non-immunosuppressive phosphatase activator, in mice, rats, and ......
期刊： AAPS JOURNAL, 2020; 22 (2)
The self-renewal and differentiation of cancer stem-like cells (CSCs) leads to cellular heterogeneity, causing one of the greatest challenges in cance......
期刊： AAPS JOURNAL, 2020; 22 (3)
Quality by design (QbD) is an efficient but challenging approach for the development of biosimilar due to the complex relationship among process, qual......
期刊： AAPS JOURNAL, 2020; 22 (4)
Physiologically-based pharmacokinetic (PBPK) modelling provides an integrated framework to predict the disposition of small molecule drugs in children......
期刊： AAPS JOURNAL, 2019; 21 (2)
Chemoimmunotherapy with chemotherapeutics and immunoadjuvant inhibits tumor growth by activating cytotoxic T cells. However, this process also upregul......
