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PKPD Modeling and Dosing Considerations in Advanced Ovarian Cancer Patients Treated with Cisplatin-Based Intraoperative Intraperitoneal Chemotherapy

Xie, FF; Van Bocxlaer, J; Colin, P; Carlier, C; Van Kerschaver, O; Weerts, J; Denys, H; Tummers, P; Willaert, W; Ceelen, W; Vermeulen, A

Xie, FF (corresponding author), Cent South Univ, Xiangya Sch Pharmaceut Sci, Div Biopharmaceut & Pharmacokinet, Tongzipo Rd 172, Changsha 410013, Peoples R China.; Xie, FF (corresponding author), Univ Ghent, Fac Pharmaceut Sci, Lab Med Biochem & Clin Anal, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

AAPS JOURNAL, 2020; 22 (5):

Abstract

Intraperitoneal chemoperfusion (IPEC) of cisplatin is a popular treatment for advanced ovarian cancer, typically under hyperthermia (HIPEC). The use o......

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