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The synthesis and activity evaluation of N-acylated analogs of echinocandin B with improved solubility and lower toxicity

Zhu, B; Dong, YZ; Ma, J; Chen, MW; Ruan, SD; Zhao, WJ; Feng, J

Feng, J (corresponding author), Shanghai Duomirui Biotechnol Ltd, Shanghai, Peoples R China.

JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (11):

Abstract

Presently, echinocandins have been recommended as the first-line drugs for the treatment of invasive candidiasis. However, low oral bioavailability an......

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