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Design of acid-activated cell-penetrating peptides with nuclear localization capacity for anticancer drug delivery

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (10)

Camptothecin (CPT), a DNA-toxin drug, exerts anticancer activity by inhibiting topoisomerase I. Targeted delivery of CPT into the cancer cell nucleus ......

Effects of N-terminal modifications on the stability of antimicrobial peptide SAMP-A4 analogues against protease degradation

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (10)

Infections with multidrug-resistant (MDR) pathogens are increasingly concerning for public health. Synthesized antimicrobial peptide A4 (SAMP-A4), a p......

Amino acid sequence identification of goji berry cyclic peptides and anticervical carcinoma activity detection

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (8)

The goji berry is widely used as tonics; however, the antihuman cervical carcinoma effect and underlying mechanism of goji berry peptide remain to be ......

Synthesis of sulfonopeptides

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (8)

Sulfonopeptides as the sulfur analogues of natural peptides have been widely used as enzyme inhibitors due to their tetrahedral sulfonamide moiety, wh......

N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (9)

Antimicrobial peptide L163 was computationally designed by our laboratory; L163 is active against multidrug-resistant (MDR) bacteria but is easily deg......

Revisiting bone morphogenetic protein-2 knuckle epitope and redesigning the epitope-derived peptides

期刊: JOURNAL OF PEPTIDE SCIENCE, ; ()

The bone morphogenetic protein-2 (BMP2) plays a crucial role in bone formation, growth and regeneration, which adopts a conformational wrist epitope a......

Composition-dependent multivalency of peptide-peptide interactions revealed by tryptophan-scanning mutagenesis

期刊: JOURNAL OF PEPTIDE SCIENCE, ; ()

We have examined in this contribution the composition dependence of binding characteristics in peptide-peptide interactions between an oligopeptide oc......

The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (5)

In this article, a series of modifications were made on an antimicrobial peptide F2,5,12W, including altering the amino acid sequence, introducing cys......

Anti-colon cancer activity tracking isolation of peptide from ginseng leaves and potential mechanisms evaluation in vitro and in vivo

期刊: JOURNAL OF PEPTIDE SCIENCE, 2021; 27 (4)

The ginseng has been used for over hundred years, in the belief of promoting longevity. However, the anticancer activity of ginseng leaf peptide (GP) ......

Acid-activated nonviral peptide vector for gene delivery

期刊: JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (1)

Nonviral vector-based gene therapy is a promising strategy for treating a myriad of diseases. Cell-penetrating peptides are gaining increasing attenti......

Esc-1GN shows therapeutic potentials for acne vulgaris and inflammatory pain

期刊: JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (8)

The inflammatory response plays important roles in acne vulgaris and pain pathogenesis. In previous study, Esc-1GN with anti-inflammatory, antimicrobi......

Inhibitory and anti-inflammatory effects of two antimicrobial peptides moronecidin and temporin-1Dra againstPropionibacterium acnesin vitro and in vivo

期刊: JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (7)

Proliferation ofPropionibacterium acnes(P.acnes) is one of the main pathogenetic mechanisms of acne. Antimicrobial peptides with low-drug resistance a......

Position-coded multivalent peptide-peptide interactions revealed by tryptophan-scanning mutagenesis

期刊: JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (9)

We demonstrate in this contribution the evidence that significant cooperative binding effect can be identified for the amino acid sites that are deter......

The synthesis and activity evaluation of N-acylated analogs of echinocandin B with improved solubility and lower toxicity

期刊: JOURNAL OF PEPTIDE SCIENCE, 2020; 26 (11)

Presently, echinocandins have been recommended as the first-line drugs for the treatment of invasive candidiasis. However, low oral bioavailability an......

Synthesis, in vitro stability, and antiproliferative effect of d-cysteine modified GnRH-doxorubicin conjugates

期刊: JOURNAL OF PEPTIDE SCIENCE, 2019; 25 (1)

Overexpression of gonadotropin-releasing hormone (GnRH) receptor in many tumors but not in normal tissues makes it possible to use GnRH analogs as tar......

JIF:2.08

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