Lentivirus-mediated RNA interference targeting FAMLF-1 inhibits cell growth and enhances cell differentiation of acute myeloid leukemia partially differentiated cells via inhibition of AKT and c-MYC-MedSci.cn

Lentivirus-mediated RNA interference targeting FAMLF-1 inhibits cell growth and enhances cell differentiation of acute myeloid leukemia partially differentiated cells via inhibition of AKT and c-MYC

Huang, YM; Zheng, Y; Li, JG; Wang, XC; Wang, ZC; Chen, WL; Pan, LL; Li, Y; Luo, DF; Wang, SY

Wang, SY (reprint author), Fujian Med Univ, Union Clin Med Coll, Fuzhou 350001, Fujian, Peoples R China.; Wang, SY (reprint author), Fujian Med Univ, Union Hosp, Fujian Prov Key Lab Hematol, Dept Hematol,Fujian Inst Hematol, Fuzhou 350001, Fujian, Peoples

ONCOTARGET, 2017; 8 (60): 101372

Abstract

Genetic heterogeneity is the basis of clinical heterogeneity among different subtypes of AML. We have successfully cloned a gene related to AML termed......

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Lentivirus-mediated RNA interference targeting FAMLF-1 inhibits cell growth and enhances cell differentiation of acute myeloid leukemia partially differentiated cells via inhibition of AKT and c-MYC

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