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Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency

Punwani, D; Kawahara, M; Yu, J; Sanford, U; Roy, S; Patel, K; Carbonaro, DA; Karlen, AD; Khan, S; Cornetta, K; Rothe, M; Schambach, A; Kohn, DB; Malech, HL; McIvor, RS; Puck, JM; Cowan, MJ

Puck, JM; Cowan, MJ (reprint author), Univ Calif San Francisco, Smith Cardiovasc Res Inst, 555 Mission Bay Blvd South,Rm SC-252K, San Francisco, CA 94158 USA.

HUMAN GENE THERAPY, 2017; 28 (1): 112

Abstract

During B and T lymphocyte maturation, V(D)J recombination is initiated by creation of DNA double-strand breaks. Artemis is an exonuclease essential fo......

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