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Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation

Lundy, TA; Mori, S; Garneau-Tsodikova, S

Garneau-Tsodikova, S (reprint author), Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA.

ORGANIC & BIOMOLECULAR CHEMISTRY, 2019; 17 (5): 1169

Abstract

The adenylation (A) domains found in nonribosomal peptide synthetases (NRPSs) exhibit tremendous plasticity. Some A domains have been shown to display......

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