Mechanistic Exploration of Methionine 274 Acting as a "Switch" of the Selective Pocket Involved in HDAC8 Inhibition: An in Silico Study-MedSci.cn

Mechanistic Exploration of Methionine 274 Acting as a "Switch" of the Selective Pocket Involved in HDAC8 Inhibition: An in Silico Study

Yao, P; Gao, QS; Wang, Y; Yao, QZ; Zhang, J

Zhang, J (corresponding author), China Pharmaceut Univ, Dept Phys Chem, Sch Sci, Nanjing 211198, Peoples R China.; Zhang, J (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China.

CHEMMEDCHEM, 2021; 16 (12): 1933

Abstract

The overexpression of histone deacetylase 8 (HDAC8) causes several diseases, and the selective inhibition of HDAC8 has been touted as a promising ther......

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Mechanistic Exploration of Methionine 274 Acting as a "Switch" of the Selective Pocket Involved in HDAC8 Inhibition: An in Silico Study

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