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Ensemble switching unveils a kinetic rheostat mechanism of the eukaryotic thiamine pyrophosphate riboswitch

Ma, JY; Saikia, N; Godar, S; Hamilton, GL; Ding, F; Alper, J; Sanabria, H

Sanabria, H (corresponding author), Ctr Opt Mat Sci & Engn Technol, Clemson, SC 29634 USA.; Ding, F; Alper, J; Sanabria, H (corresponding author), Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA.; Alper, J (corresponding author), Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA.; Alper, J (corresponding author), Clemson Univ, Eukaryot Pathogen Innovat Ctr, Clemson, SC 29634 USA.

RNA, 2021; 27 (7): 771

Abstract

Thiamine pyrophosphate (TPP) riboswitches regulate thiamine metabolism by inhibiting the translation of enzymes essential to thiamine synthesis pathwa......

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