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Pirfenidone reduces immune-suppressive capacity of cancer-associated fibroblasts through targeting CCL17 and TNF-beta

Es, HA; Zhand, S; Thiery, JP; Warkiani, ME

Warkiani, ME (corresponding author), Univ Technol Sydney, Fac Engn & Informat Technol, Sch Biomed Engn, Sydney, NSW, Australia.; Warkiani, ME (corresponding author), Sechenov Univ, Inst Mol Med, Moscow, Russia.

INTEGRATIVE BIOLOGY, 2020; 12 (7): 188

Abstract

Various factors in the tumor microenvironment (TME) regulate the expression of PD-L1 in carcinoma cells. The cancer-associated fibroblasts (CAFs) play......

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