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Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint

期刊: INTEGRATIVE BIOLOGY, 2021; 13 (1)

Tumor emboli-aggregates of tumor cells within vessels-pose a clinical challenge as they are associated with increased metastasis and tumor recurrence.......

A novel two layer-integrated microfluidic device for high-throughput yeast proteomic dynamics analysis at the single-cell level

期刊: INTEGRATIVE BIOLOGY, 2020; 12 (10)

Current microfluidic methods for studying multicell strains (e.g., m-types) with multienvironments (e.g., n-types) require large numbers of inlets/out......

Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment

期刊: INTEGRATIVE BIOLOGY, 2020; 12 (4)

Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices to cancer cells for their invasion. Studies have explored the bio......

Pirfenidone reduces immune-suppressive capacity of cancer-associated fibroblasts through targeting CCL17 and TNF-beta

期刊: INTEGRATIVE BIOLOGY, 2020; 12 (7)

Various factors in the tumor microenvironment (TME) regulate the expression of PD-L1 in carcinoma cells. The cancer-associated fibroblasts (CAFs) play......

Protein-ligand interaction fingerprints for accurate prediction of dissociation rates of p38 MAPK Type II inhibitors

期刊: INTEGRATIVE BIOLOGY, 2019; 11 (2)

Binding/unbinding kinetics are key determinants of drug potencies. However, there are still a lot of challenges in predicting kinetic properties durin......

JIF:2.77

Protein dynamic analysis of the budding yeast sporulation process at the single-cell level in an air-enriched microfluidic device

期刊: INTEGRATIVE BIOLOGY, 2019; 11 (3)

The sporulation process of the budding yeast Saccharomyces cerevisiae involves morphological changes, which is a complex and interesting process in ye......

JIF:2.77

3D-Printed seed planter and well array for high-throughput seed germination screening

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (1)

Seed germination is an important means of evaluating seed quality. In the present study, a well array for a seed germination experiment was designed a......

JIF:2.77

Landscape of gene networks for random parameter perturbation

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (2)

Landscape approaches have been exploited to study the stochastic dynamics of gene networks. However, how to calculate the landscape with a wide range ......

JIF:2.77

Detection of microalgae superoxide dismutase (SOD) using a GNRs-based resonance light scattering system

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (3)

A novel and label-free, gold nanorods (GNRs)-based resonance light scattering system assay has been developed for the detection of microalgae superoxi......

JIF:2.77

Co-detection of ALDH1A1, ABCG2, ALCAM and CD133 in three A549 subpopulations at the single cell level by one-step digital RT-PCR

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (6)

Cancer stem-like cells (CSCs) displaying the properties of normal stem cells have become the main culprit associated with cancer transportation and re......

JIF:2.77

Different angiogenesis modes and endothelial responses in implanted porous biomaterials

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (7)

An in vivo experimental model based on implanting porous biomaterials to study angiogenesis was proposed. In the implanted porous polyvinyl alcohol, t......

JIF:2.77

Engineering of a genetic circuit with regulatable multistability

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (8)

Synthetic biologists are dedicated to designing genetic systems from the bottom up to understand how living systems work. To date, a variety of geneti......

JIF:2.77

Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (12)

Human hepatic C3A cells have been applied in bioartificial liver development, although these cells display low intrinsic cytochrome P450 3A4 (CYP3A4) ......

JIF:2.77

Computational model of wound healing: EGF secreted by fibroblasts promotes delayed re-epithelialization of epithelial keratinocytes

期刊: INTEGRATIVE BIOLOGY, 2018; 10 (10)

It is widely agreed that keratinocyte migration plays a crucial role in wound re-epithelialization. Defects in this function contribute to wound reocc......

JIF:2.77

Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells

期刊: INTEGRATIVE BIOLOGY, 2017; 9 (3)

Detection of rare circulating tumor cells (CTCs) in peripheral blood is a challenging, but necessary, task in order to diagnose early onset of metasta......

JIF:3.29

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