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Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment

Lee, SWL; Seager, RJ; Litvak, F; Spill, F; Sieow, JL; Leong, PH; Kumar, D; Tan, ASM; Wong, SC; Adriani, G; Zaman, MH; Kamm, RD

Adriani, G (corresponding author), ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore.; Zaman, MH (corresponding author), Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.; Kamm, RD (corresponding author), MIT, Dept Mech Engn, Cambridge, MA 02139 USA.; Zaman, MH (corresponding author), Boston Univ, Howard Hughes Med Inst, Boston, MA 02215 USA.; Kamm, RD (corresponding author), MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.

INTEGRATIVE BIOLOGY, 2020; 12 (4): 90

Abstract

Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices to cancer cells for their invasion. Studies have explored the bio......

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