Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex-MedSci.cn

Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex

Han, S; Wei, SR; Wang, X; Han, X; Zhang, MZ; Su, M; Li, Y; Guo, JH; Zeng, WT; Liu, JW; Gao, Y; Shen, L

Han, S; Wei, SR; Shen, L (reprint author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China.; Han, S (reprint author), Capital Med Univ, Beijing Chao Yang Hosp, Med Ctr Human Reprod, Beijing 100020, Peoples R C

Abstract

Human hepatic C3A cells have been applied in bioartificial liver development, although these cells display low intrinsic cytochrome P450 3A4 (CYP3A4) ......

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Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex

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