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Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Bradycardiac Effects Caused by Co-Administration of Sofosbuvir and Amiodarone

Yu, YK; Liu, F; He, LM; Ramakrishna, S; Zheng, M; Bu, L; Xu, Y

Zheng, M (reprint author), Guangdong iPSyte Biosci Co Ltd, 3 Juquan Rd Sci City, Guangzhou 510600, Guangdong, Peoples R China.; Bu, L (reprint author), NYU, Sch Med, Helen L & Martin S Kimmel Ctr Stem Cell Biol, Leon H Charney Div Cardiol,Dept Cell Biol,D

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2018; 16 (4): 222

Abstract

Co-administration of sofosbuvir, an anti-hepatitis C virus medication, and antiarrhythmic amiodarone causes symptomatic severe bradycardia in patients......

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