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A Cannabinoid-1 Receptor Antagonist MJ08 with Different Effects in Stomach and Small Intestine

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2021; 19 (3)

Background: To investigate the inverse agonistic effect of a novel type 1 cannabinoid (CB1) receptor antagonist, MJ08, on the gastrointestinal tract (......

A Modified MTS Proliferation Assay for Suspended Cells to Avoid the Interference by Hydralazine and beta-Mercaptoethanol

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, ; ()

The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay is one of the most commonly used tests of cel......

An Improved 3-(4,5-Dimethylthiazol-2-yl)-5-(3-Carboxymethoxyphenyl)-2-(4-Sulfophenyl)-2H-Tetrazolium Proliferation Assay to Overcome the Interference of Hydralazine

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2020; 18 (8)

The MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay is one of the most commonly used assays to as......

Development and Characterization of a Glimepiride-Loaded Gelatin-Coated Mesoporous Hollow Silica Nanoparticle Formulation and Evaluation of Its Hypoglycemic Effect on Type-2 Diabetes Model Rats

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2020; 18 (8)

In this study, we prepared gelatin-coated mesoporous hollow silica nanospheres (GSN) as a drug carrier to improve the water solubility and regulate th......

Analysis and Quantification of Oxidized Low-Density Lipoprotein-Induced Lipid Droplets in Macrophages Through High-Content Screening: Application for Antiatherogenic Drugs Discovery

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2019; 17 (5)

In vascular systems, macrophages can engulf circulating oxidized (ox) low-density lipoprotein (LDL), leading to the accumulation of intracellular lipi......

JIF:1.42

Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2019; 17 (6)

Phospholipid biosynthesis begins with the acylation of glycerol 3-phosphate (G3P). In most Gram-positive bacteria including many pathogens, a membrane......

JIF:1.42

Integration of Antibody Array Technology into Drug Discovery and Development

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2018; 16 (2)

Antibody arrays represent a high-throughput technique that enables the parallel detection of multiple proteins with minimal sample volume requirements......

JIF:1.42

Preparation of Vitamin E-Containing High-Density Lipoprotein and Its Protective Efficacy on Macrophages

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2018; 16 (2)

Atherosclerosis is a major cause for cardiovascular diseases. High-density lipoprotein (HDL) may reduce atherosclerosis through several different mech......

JIF:1.42

Ebselen Reversibly Inhibits Human Glutamate Dehydrogenase at the Catalytic Site

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2018; 16 (2)

Human glutamate dehydrogenase (GDH) plays an important role in neurological diseases, tumor metabolism, and hyperinsulinism-hyperammonemia syndrome (H......

JIF:1.42

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Bradycardiac Effects Caused by Co-Administration of Sofosbuvir and Amiodarone

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2018; 16 (4)

Co-administration of sofosbuvir, an anti-hepatitis C virus medication, and antiarrhythmic amiodarone causes symptomatic severe bradycardia in patients......

JIF:1.42

Rapid High-Throughput Assay Identified Gemcitabine and Derivatives As Potent Inhibitors Against Multidrug-Resistant Staphylococcus aureus

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2022; 20 (4)

Methicillin-resistant Staphylococcus aureus (MRSA) are challenging pathogenic bacteria that can cause severe infection leading to high mortality rates......

JIF:1.314

Developmental Cardiotoxicity and Hepatotoxicity of Flurbiprofen Axetil to Zebrafish Embryo

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2022; 20 (3)

Flurbiprofen axetil (FA) is a nonsteroidal targeted analgesic and widely used for postoperative analgesia and cancer analgesia. Extensive works have b......

JIF:1.314

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