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Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis

Vacca, M; Leslie, J; Virtue, S; Lam, BYH; Govaere, O; Tiniakos, D; Snow, S; Davies, S; Petkevicius, K; Tong, Z; Peirce, V; Nielsen, MJ; Ament, Z; Li, W; Kostrzewski, T; Leeming, DJ; Ratziu, V; Allison, MED; Anstee, QM; Griffin, JL; Oakley, F; Vidal-Puig, A

Vacca, M; Vidal-Puig, A (corresponding author), Univ Cambridge, WT MRC Inst Metab Sci, MRC Metab Dis Unit, TVP Lab,Metab Res Labs, Cambridge, England.; Vacca, M (corresponding author), Univ Cambridge, Dept Biochem, Cambridge, England.; Vacca, M (corresponding author), Univ Cambridge, Cambridge Syst Biol Ctr, Cambridge, England.; Vidal-Puig, A (corresponding author), Welcome Trust Sanger Inst, Hinxton, England.; Vidal-Puig, A (corresponding author), Cambridge Univ Nanjing Ctr Technol & Innovat, Nanjing, Peoples R China.

NATURE METABOLISM, 2020; 2 (6): 514

Abstract

Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The m......

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