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Twisted Silica Microstructured Optical Fiber with Equiangular Spiral Six-Ray Geometry

期刊: FIBERS, 2021; 9 (5)

This work presents fabricated silica microstructured optical fiber with special equiangular spiral six-ray geometry, an outer diameter of 125 mu m (th......

Formation of Polysulfone Hollow Fiber Membranes Using the Systems with Lower Critical Solution Temperature

期刊: FIBERS, 2021; 9 (5)

This study deals with the investigation of the phase state of the polymer systems from polysulfone (PSF) with the addition of polyethylene glycol (PEG......

Flexural Performance of a New Hybrid Basalt-Polypropylene Fiber-Reinforced Concrete Oriented to Concrete Pipelines

期刊: FIBERS, 2021; 9 (7)

The bending performance of a basalt-polypropylene fiber-reinforced concrete (HBPFRC) was characterized by testing 24,400 x 100 x 100 mm(3) prismatic s......

High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

期刊: NATURE METABOLISM, 2020; 2 (1)

High-protein diets are commonly utilized for weight loss, yet they have been reported to raise cardiovascular risk. The mechanisms underlying this ris......

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

期刊: NATURE METABOLISM, 2020; 2 (2)

The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the......

Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities

期刊: NATURE METABOLISM, 2020; 2 (2)

Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenviro......

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

期刊: NATURE METABOLISM, 2020; 2 (3)

The transcriptional role of cMyc (or Myc) in tumorigenesis is well appreciated; however, it remains to be fully established how extensively Myc is inv......

Single-cell omics in ageing: a young and growing field

期刊: NATURE METABOLISM, 2020; 2 (4)

Organismal ageing results from interlinked molecular changes in multiple organs over time. The study of ageing at the molecular level is complicated b......

KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth

期刊: NATURE METABOLISM, 2020; 2 (12)

The oncogenic KRAS mutation has a critical role in the initiation of human pancreatic ductal adenocarcinoma (PDAC) since it rewires glutamine metaboli......

HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry

期刊: NATURE METABOLISM, 2020; 2 (12)

Responsible for the ongoing coronavirus disease 19 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cell......

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

期刊: NATURE METABOLISM, 2020; 2 (12)

A particularly aggressive subtype of lung cancer with mutations in KRAS and LKB1 is shown to depend on increased hexosamine biosynthesis mediated by t......

MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism

期刊: NATURE METABOLISM, 2020; 2 (5)

The rhythmic regulation of transcriptional processes is intimately linked to lipid homeostasis, to anticipate daily changes in energy access. The Rev-......

A functional non-conserved long non-coding RNA in human adipose tissue

期刊: NATURE METABOLISM, 2020; 2 (5)

Thermogenic adipocytes can burn lipids and carbohydrates for heat generation. The finding that a primate-specific long non-coding RNA regulates lipoly......

Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis

期刊: NATURE METABOLISM, 2020; 2 (6)

Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The m......

The small intestine shields the liver from fructose-induced steatosis

期刊: NATURE METABOLISM, 2020; 2 (7)

Per capita fructose consumption has increased 100-fold over the last century(1). Epidemiological studies suggest that excessive fructose consumption, ......

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