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High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

Zhang, XY; Sergin, I; Evans, TD; Jeong, SJ; Rodriguez-Velez, A; Kapoor, D; Chen, S; Song, E; Holloway, KB; Crowley, JR; Epelman, S; Weihl, CC; Diwan, A; Fan, DP; Mittendorfer, B; Stitziel, NO; Schilling, JD; Lodhi, IJ; Razani, B

Razani, B (corresponding author), Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63110 USA.; Razani, B (corresponding author), Washington Univ, Sch Med, Dept Nutr, St Louis, MO 63110 USA.; Razani, B (corresponding author), Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.

NATURE METABOLISM, 2020; 2 (1): 110

Abstract

High-protein diets are commonly utilized for weight loss, yet they have been reported to raise cardiovascular risk. The mechanisms underlying this ris......

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