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KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth

Raho, S; Capobianco, L; Malivindi, R; Vozza, A; Piazzolla, C; De Leonardis, F; Gorgoglione, R; Scarcia, P; Pezzuto, F; Agrimi, G; Barile, SN; Pisano, I; Reshkin, SJ; Greco, MR; Cardone, RA; Rago, V; Li, Y; Marobbio, CMT; Sommergruber, W; Riley, CL; Lasorsa, FM; Mills, E; Vegliante, MC; De Benedetto, GE; Fratantonio, D; Palmieri, L; Dolce, V; Fiermonte, G

Fiermonte, G (corresponding author), Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy.; Dolce, V (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende, Italy.; Fiermonte, G (corresponding author), CNR, Inst Biomembranes & Bioenerget, Bari, Italy.

NATURE METABOLISM, 2020; 2 (12):

Abstract

The oncogenic KRAS mutation has a critical role in the initiation of human pancreatic ductal adenocarcinoma (PDAC) since it rewires glutamine metaboli......

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