Baidu
map

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Kim, J; Lee, HM; Cai, F; Ko, B; Yang, CD; Lieu, EL; Muhammad, N; Rhyne, S; Li, KL; Haloul, M; Gu, W; Faubert, B; Kaushik, AK; Cai, L; Kasiri, S; Marriam, U; Nham, K; Girard, L; Wang, H; Sun, XK; Kim, J; Minna, JD; Unsal-Kacmaz, K; DeBerardinis, RJ

Kim, J (corresponding author), Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA.; DeBerardinis, RJ (corresponding author), UT Southwestern Med Ctr, Childrens Med Ctr, Res Inst, Dallas, TX 75390 USA.; DeBerardinis, RJ (corresponding author), UT Southwestern Med Ctr, Dept Pediat, Dallas, TX 75390 USA.; DeBerardinis, RJ (corresponding author), UT Southwestern Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA.; DeBerardinis, RJ (corresponding author), UT Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA.

NATURE METABOLISM, 2020; 2 (12):

Abstract

A particularly aggressive subtype of lung cancer with mutations in KRAS and LKB1 is shown to depend on increased hexosamine biosynthesis mediated by t......

Full Text Link


Baidu
map
Baidu
map
Baidu
map