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Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions

Thevenin, M; Chen, G; Kantham, S; Sun, CX; Glogauer, M; Young, RN

Young, RN (corresponding author), Simon Fraser Univ, Dept Chem, Burnaby, BC V5Z 4B4, Canada.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2021; 4 (2): 908

Abstract

A series of bone-targeting EP4 receptor agonist conjugate prodrugs were prepared wherein a potent EP4 receptor agonist was bound to a biologically ina......

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