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Enhancing Efficacy of TCR-engineered CD4+ T Cells Via Coexpression of CD8α

Anderson, VE; Brilha, SS; Weber, AM; Pachnio, A; Wiedermann, GE; Dauleh, S; Ahmed, T; Pope, GR; Quinn, LL; Docta, RY; Quattrini, A; Masters, S; Cartwright, N; Viswanathan, P; Melchiori, L; Rice, LV; Sevko, A; Gueguen, C; Saini, M; Tavano, B; Abbott, RJM; Silk, JD; Laugel, B; Sanderson, JP; Gerry, AB

Anderson, VE (通讯作者),Adaptimmune, 60 Jubilee Ave, Abingdon OX14 4RX, Oxon, England.

JOURNAL OF IMMUNOTHERAPY, 2023; 46 (4): 132

Abstract

Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing......

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