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Molecular modeling studies of [4-(3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors

Lv, H; Du, YL; Sheng, XH; Gao, ZP; Shen, JK

Du, YL (corresponding author), Qilu Univ Technol, Sch Chem & Chem Engn, Shandong Acad Sci, 3501 Da Xue Rd, Jinan 250353, Peoples R China.; Sheng, XH (corresponding author), Shandong Normal Univ, Coll Chem, Chem Engn & Mat Sci, 88 Wen Hua Dong Rd, Jinan 250014, Peoples R China.

FUTURE MEDICINAL CHEMISTRY, 2021; 13 (16): 1317

Abstract

Aim: CDK4 is a promising target for breast cancer therapy. This study aimed to explore the structure-activity relationship of CDK4 inhibitor abemacicl......

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