Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir-MedSci.cn

Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir

Xia, ZL; Sacco, M; Hu, YM; Ma, CL; Meng, XZ; Zhang, FS; Szeto, T; Xiang, Y; Chen, Y; Wang, J

Wang, J (corresponding author), Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA.; Chen, Y (corresponding author), Univ S Florida, Morsani Coll Med, Dept Mol Med, Tampa, FL 33612 USA.

Abstract

SARS-CoV-2 main protease (M-Pro) is a cysteine protease that mediates the cleavage of viral polyproteins and is a validated antiviral drug target. M-P......

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Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir

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