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Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability

Yang, LH; Wu, PH; Xu, JC; Xie, DH; Wang, ZQ; Wang, Q; Chen, Y; Li, CH; Zhang, JX; Chen, HP; Quan, GL

Chen, Y (corresponding author), HEC Pharm Grp, HEC Res & Dev Ctr, Dongguan 523871, Peoples R China.; Chen, Y (corresponding author), Xiangnan Univ, Hunan Prov Key Lab Xiangnan Rare Precious Met Cpd, Coll Chem Biol & Environm Engn, Chenzhou 423043, Peoples R China.

AAPS PHARMSCITECH, 2021; 22 (4):

Abstract

Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with activ......

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