期刊： AAPS PHARMSCITECH, 2021; 22 (4)
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with activ......
期刊： AAPS PHARMSCITECH, 2021; 22 (5)
Chemical penetration enhancers (CPEs) are commonly added into transdermal patches to impart improved skin permeation of drug. However, significant une......
期刊： AAPS PHARMSCITECH, 2021; 22 (5)
This research aimed to develop a novel drug delivery system to improve treatment of skin disorders. The system is comprised of a Carbopol 980-based na......
期刊： AAPS PHARMSCITECH, 2021; 22 (7)
3-O-beta-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-beta-D-galactose (Gal) in our previous study. In order ......
期刊： AAPS PHARMSCITECH, 2021; 22 (7)
The postprandial glycemic regulation is essential for diabetic patients to reduce the risk of long-term microvascular and macrovascular complications.......
期刊： AAPS PHARMSCITECH, 2021; 22 (7)
Geniposide (GE) possesses excellent neuroprotective effects but with poor brain targeting and short half-life. Liposome was considered to have great p......
期刊： AAPS PHARMSCITECH, 2021; 22 (4)
Chemical enhancers (CEs) decreased the barrier of the stratum corneum (SC) to enhance drug permeation. This was a "dynamic" behavior, which involved t......
期刊： AAPS PHARMSCITECH, 2021; 22 (3)
This study sought to improve the oral bioavailability and enhance the anti-enteritis effect of fraxetin by incorporating it into long circulating lipo......
期刊： AAPS PHARMSCITECH, 2021; 22 (5)
With the limitation of solubility and dissolution rate of insoluble drugs, following oral administration, they would rifely prove poor and volatile bi......
期刊： AAPS PHARMSCITECH, 2021; 22 (3)
The main objective of this study was to develop an in vivo predictive dissolution (IVPD) model for topiroxostat immediate-release (IR) formulation by ......
期刊： AAPS PHARMSCITECH, 2021; 22 (6)
Drug-loaded electrospun fibers have attracted increasing attention as a promising wound dressing material due to their capability of preventing from i......
期刊： AAPS PHARMSCITECH, 2021; 22 (6)
The orally available novel small molecule drug ZWF is under preclinical development for an anticancer purpose. The present study aimed to assess the v......
期刊： AAPS PHARMSCITECH, 2021; 22 (5)
The aim of this study was to investigate the effect of various parameters on the stability of butorphanol tartrate injection and to screen the optimal......
期刊： AAPS PHARMSCITECH, 2021; 22 (6)
Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, ......
期刊： AAPS PHARMSCITECH, 2021; 22 (6)
To improve the bioavailability of puerarin in liver, the optimized preparation method of puerarin-PLGA nanoparticles (Pue-PLGA-nps) and the effect of ......
