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Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond

Vasta, JD; Choudhary, A; Jensen, KH; McGrath, NA; Raines, RT

Raines, RT (reprint author), Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA.; Raines, RT (reprint author), Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA.

BIOCHEMISTRY, 2017; 56 (1): 219

Abstract

Collagen prolyl 4-hydroxylases (CP4Hs) catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollage......

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