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An Effective and Convenient Process for the Preparation of Ticagrelor: Optimized by Response Surface Methodology and One-Pot Reaction

Wang, LH; Liu, JH

Wang, LH (reprint author), Qingdao Univ Sci & Technol, Dept Pharmaceut Engn, 53 Zhengzhou Rd, Qingdao 266000, Shandong, Peoples R China.

PHARMACEUTICAL CHEMISTRY JOURNAL, 2019; 52 (10): 813

Abstract

An effective and convenient process for the preparation of ticagrelor (1), an antiplatelet drug, has been developed. The synthesis of 1 is a four-step......

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