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A Matrigel-based 3D construct of SH-SY5Y cells models the alpha-synuclein pathologies of Parkinson's disease

Li, ZF; Cui, L; Jin, MM; Hu, DY; Hou, XG; Liu, SS; Zhang, X; Zhu, JH

Zhu, JH (通讯作者),Wenzhou Med Univ, Inst Nutr & Dis, Dept Prevent Med, Wenzhou 325035, Zhejiang, Peoples R China.;Zhang, X; Zhu, JH (通讯作者),Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol & Geriatr, Wenzhou 325027, Zhejiang, Peoples R China.;Zhang, X; Zhu, JH (通讯作者),Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China.

DISEASE MODELS & MECHANISMS, 2022; 15 (3):

Abstract

Parkinson's disease (PD) is associated with alpha-synuclein-based Lewy body pathology, which has been difficult to observe in conventional two-dimensi......

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