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Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1

Zhao, XQ; Ma, Y; Shi, MA; Huang, ML; Xin, JY; Ci, SS; Chen, MM; Jiang, T; Hu, ZG; He, LF; Pan, FY; Guo, ZG

Pan, FY; Guo, ZG (通讯作者),Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, 1 WenYuan Rd, Nanjing 210023, Peoples R China.

CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (6):

Abstract

Although iron overload is closely related to the occurrence of type 2 diabetes mellitus (T2DM), the specific mechanism is unclear. Here, we found that......

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