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A novel twin-column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants

Jing, SY; Shi, C; Leong, HY; Yuan, JJ; Gao, D; Wang, HB; Yao, SJ; Lin, DQ

Lin, DQ (corresponding author), Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Peoples R China.

ENGINEERING IN LIFE SCIENCES, 2021; 21 (6): 382

Abstract

Downstream processing of mAb charge variants is difficult owing to their similar molecular structures and surface charge properties. This study aimed ......

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