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Submicron Aggregation of Chemically Denatured Monoclonal Antibody

Rowe, JB; Flynn, RP; Wooten, HR; Noufer, HA; Cancel, RA; Zhang, JF; Subramony, JA; Pechenov, S; Wang, Y

Wang, Y (reprint author), Univ N Carolina, Dept Chem & Biochem, Wilmington, NC 28403 USA.; Pechenov, S (reprint author), MedImmune, One MedImmune Way, Gaithersburg, MD 20878 USA.; Wang, Y (reprint author), Univ N Carolina, Dept Chem, Dobo 122,4978 Cahill

MOLECULAR PHARMACEUTICS, 2018; 15 (10): 4710

Abstract

Isothermal chemical denaturation (ICD) has been widely used to evaluate the conformational stability of therapeutic proteins such as monoclonal antibo......

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