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Synthesis and activity of miconazole derivatives as dual BChE/IDO1 inhibitors for the treatment of Alzheimer's disease

Lu, X; Liu, YJ; Qin, N; Yang, HY; Qiao, YT; Jiang, XY; Chen, Y; Feng, F; Liu, WY; Zhou, Y; Sun, HP

Sun, HP (corresponding author), China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.; Sun, HP (corresponding author), Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China.; Zhou, Y (corresponding author), Southwest Univ, Coll Sericulture Textile & Biomass Sci, Chongqing 400715, Peoples R China.

FUTURE MEDICINAL CHEMISTRY, 2021; 13 (13): 1105

Abstract

Background: Alzheimer's disease is a multifactorial neurological disorder seen in elderly people. Loss of cholinergic transmission and unbalanced tryp......

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