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Exaptation of two ancient immune proteins into a new dimeric pore-forming toxin in snails

Giglio, ML; Ituarte, S; Milesi, V; Dreon, MS; Brola, TR; Caramelo, J; Ip, JCH; Mate, S; Qiu, JW; Otero, LH; Heras, H

Otero, LH (corresponding author), Consejo Nacl Invest Cient & Tecn, Fdn Inst Leloir, IIBBA, Av Patricias Argentinas 435,C1405BWE, Buenos Aires, DF, Argentina.; Heras, H (corresponding author), Univ Nacl La Plata UNLP, CONICET, Inst Invest Bioquim La Plata INIBIOLP, RA-1900 La Plata, Argentina.

JOURNAL OF STRUCTURAL BIOLOGY, 2020; 211 (2):

Abstract

The Membrane Attack Complex-Perforin (MACPF) family is ubiquitously found in all kingdoms. They have diverse cellular roles, however MACPFs with pore-......

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