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iRhom2 inhibits bile duct obstruction-induced liver fibrosis

Sundaram, B; Behnke, K; Belancic, A; Al-Salihi, MA; Thabet, Y; Polz, R; Pellegrino, R; Zhuang, Y; Shinde, PV; Xu, HC; Vasilevska, J; Longerich, T; Herebian, D; Mayatepek, E; Bock, HH; May, P; Kordes, C; Aghaeepour, N; Mak, TW; Keitel, V; Haussinger,

Lang, PA (reprint author), Heinrich Heine Univ Dusseldorf, Med Fac, Dept Mol Med 2, Univ Str 1, D-40225 Dusseldorf, Germany.

SCIENCE SIGNALING, 2019; 12 (605):

Abstract

Chronic liver disease can induce prolonged activation of hepatic stellate cells, which may result in liver fibrosis. Inactive rhomboid protein 2 (iRho......

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