左氧氟沙星-话题@MedSci - 梅斯（MedSci）

#左氧氟沙星#

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[GetTopicListResponse(id=2196023, encodeId=48fc21960235a, content=<a href='/topic/show?id=a04166612d3' target=_blank style='color:#2F92EE;'>#滴眼液#</a> <a href='/topic/show?id=7f7848124f5' target=_blank style='color:#2F92EE;'>#左氧氟沙星#</a> <a href='/topic/show?id=10296839318' target=_blank style='color:#2F92EE;'>#环丙沙星#</a> <a href='/topic/show?id=6b1b8e9908a' target=_blank style='color:#2F92EE;'>#莫西沙星#</a>, objectTitle=左氧氟沙星、环丙沙星、莫西沙星......儿童“沙星类”滴眼液如何选？, objectType=article, longId=819466, objectId=f2c6819466d9, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/267914-eye.jpg, objectUrl=/article/show_article.do?id=f2c6819466d9, replyNumber=0, likeNumber=93, createdTime=2024-03-29, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=f2c6819466d9, moduleTitle=左氧氟沙星、环丙沙星、莫西沙星......儿童“沙星类”滴眼液如何选？, moduleType=article, 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userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2128482, encodeId=01d821284827e, content=<a href='/topic/show?id=87a05084168' target=_blank style='color:#2F92EE;'>#德拉沙星#</a>(delafloxacin)由Wakunaga制药公司研发，后授权Melinta制药公司开发的新一代广谱<a href='/topic/show?id=77386391e6b' target=_blank style='color:#2F92EE;'>#氟喹诺酮类#</a>抗生素。2017年，美国FDA批准德拉沙星(商品名BaxdelaTM)上市，用于治疗由易感细菌引起的<a href='/topic/show?id=2a061054849f' target=_blank style='color:#2F92EE;'>#急性细菌性皮肤和皮肤结构感染#</a>(ABSSSI)。跟<a href='/topic/show?id=7f7848124f5' target=_blank style='color:#2F92EE;'>#左氧氟沙星#</a>、<a href='/topic/show?id=10296839318' target=_blank style='color:#2F92EE;'>#环丙沙星#</a>、<a href='/topic/show?id=6b1b8e9908a' target=_blank style='color:#2F92EE;'>#莫西沙星#</a>这些正负电荷中心分离(zwitterion)的喹诺酮类药物不同，德拉沙星C7位上的胺碱性不够强，因此，德拉沙星整个分子有弱酸性(pKa5.4)。在异噬溶酶体里面(pH5~5.5)，德拉沙星主要以中性分子形式存在，这有助于其通过细胞膜渗透入细菌内。这可以解释为什么在酸性环境下德拉沙星的最低抑菌浓度比其它<a href='/topic/show?id=50734018e17' target=_blank style='color:#2F92EE;'>#喹诺酮类#</a>化合物要低2~32倍。对<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>，德拉沙星在pH5.5时的最低抑菌浓度比pH7.4时低了5~7倍，达到了0.00003μg/mL。与其他氟喹诺酮类抗菌药物相比，德拉沙星具有更优异的<a href='/topic/show?id=fd5610598e6d' target=_blank style='color:#2F92EE;'>#抗革兰阳性菌#</a>活性。目前市场上最好的抗革兰阳性菌的氟喹诺酮类抗生素是莫西沙星，而德拉沙星对多数革兰阳性菌的最低抑菌浓度(MIC)是莫西沙星的1/2~1/4，对<a href='/topic/show?id=0b1b1059883f' target=_blank style='color:#2F92EE;'>#甲氧西林敏感金黄色葡萄菌#</a>(MSSA)和<a href='/topic/show?id=aee48036e21' target=_blank style='color:#2F92EE;'>#耐甲氧西林金黄色葡萄球菌#</a>(MRSA)的MIC90分别为0.008和0.5μg/mL。临床Ⅲ期实验显示，德拉沙星的疗效与<a href='/topic/show?id=79b51952ee8' target=_blank style='color:#2F92EE;'>#万古霉素#</a>和<a href='/topic/show?id=7ebf64048c3' target=_blank style='color:#2F92EE;'>#氨曲南#</a>联合使用的作用相当。另外，德拉沙星对革兰阴性菌和厌氧菌也有抑制活性，包括大肠埃希菌、难辨棱状芽孢杆菌等。研究表明，德拉沙星有可能作为多种严重感染的替代治疗药物，包括<a href='/topic/show?id=8efc10598902' target=_blank style='color:#2F92EE;'>#复杂性皮肤感染#</a>、<a href='/topic/show?id=fd6c356044b' target=_blank style='color:#2F92EE;'>#医院获得性肺炎#</a>、<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>以及其他重症感染性疾病。德拉沙星的药用形式为德拉沙星葡甲胺盐，可静脉给药或口服使用；不良反应包括恶心、腹泻、头痛、转氨酶升高和呕吐等。, objectTitle=2021 NICE证据总结：抗菌药物处方:delafloxacin治疗社区获得性肺炎【ES37】, objectType=guider, longId=22636, objectId=11a231c002999e48, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/guideline/show_article.do?id=11a231c002999e48, replyNumber=0, likeNumber=126, createdTime=2023-04-26, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=香港, moduleDTOList=[ModuleDTO(moduleId=11a231c002999e48, moduleTitle=2021 NICE证据总结：抗菌药物处方:delafloxacin治疗社区获得性肺炎【ES37】, moduleType=guider, hrefUrl=//m.capotfarm.com/guideline/show_article.do?id=11a231c002999e48)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=1530109, encodeId=de4b1530109ba, content=<a href='/topic/show?id=7f7848124f5' target=_blank style='color:#2F92EE;'>#左氧氟沙星#</a>, 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userId=4c37265, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=430c9255e4e, moduleTitle=「警惕」左氧氟沙星注射剂的严重不良反应！, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=430c9255e4e)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

左氧氟沙星

2020-05-29

梅斯管理员 (审核中...)

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#滴眼液# #左氧氟沙星# #环丙沙星# #莫西沙星#

左氧氟沙星、环丙沙星、莫西沙星......儿童“沙星类”滴眼液如何选？

2024-03-29发表于上海

梅斯管理员 (审核中...)

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#抗菌药物# #左氧氟沙星#

关于左氧氟沙星，你至少需要知道以下五点

2023-12-27发表于上海

侠胆医心 (审核中...)

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全文收起 #德拉沙星#(delafloxacin)由Wakunaga制药公司研发，后授权Melinta制药公司开发的新一代广谱#氟喹诺酮类#抗生素。2017年，美国FDA批准德拉沙星(商品名BaxdelaTM)上市，用于治疗由易感细菌引起的#急性细菌性皮肤和皮肤结构感染#(ABSSSI)。跟#左氧氟沙星#、#环丙沙星#、#莫西沙星#这些正负电荷中心分离(zwitterion)的喹诺酮类药物不同，德拉沙星C7位上的胺碱性不够强，因此，德拉沙星整个分子有弱酸性(pKa5.4)。在异噬溶酶体里面(pH5~5.5)，德拉沙星主要以中性分子形式存在，这有助于其通过细胞膜渗透入细菌内。这可以解释为什么在酸性环境下德拉沙星的最低抑菌浓度比其它#喹诺酮类#化合物要低2~32倍。对#金黄色葡萄球菌#，德拉沙星在pH5.5时的最低抑菌浓度比pH7.4时低了5~7倍，达到了0.00003μg/mL。与其他氟喹诺酮类抗菌药物相比，德拉沙星具有更优异的#抗革兰阳性菌#活性。目前市场上最好的抗革兰阳性菌的氟喹诺酮类抗生素是莫西沙星，而德拉沙星对多数革兰阳性菌的最低抑菌浓度(MIC)是莫西沙星的1/2~1/4，对#甲氧西林敏感金黄色葡萄菌#(MSSA)和#耐甲氧西林金黄色葡萄球菌#(MRSA)的MIC90分别为0.008和0.5μg/mL。临床Ⅲ期实验显示，德拉沙星的疗效与#万古霉素#和#氨曲南#联合使用的作用相当。另外，德拉沙星对革兰阴性菌和厌氧菌也有抑制活性，包括大肠埃希菌、难辨棱状芽孢杆菌等。研究表明，德拉沙星有可能作为多种严重感染的替代治疗药物，包括#复杂性皮肤感染#、#医院获得性肺炎#、#心内膜炎#以及其他重症感染性疾病。德拉沙星的药用形式为德拉沙星葡甲胺盐，可静脉给药或口服使用；不良反应包括恶心、腹泻、头痛、转氨酶升高和呕吐等。

2021 NICE证据总结：抗菌药物处方:delafloxacin治疗社区获得性肺炎【ES37】

2023-04-26发表于香港

cqlidoudou (审核中...)

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#左氧氟沙星#

主任查房：左氧氟沙星应该 qd 还是 bid？每次多少毫克？

2022-07-07

cqlidoudou (审核中...)

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#左氧氟沙星#

氧氟沙星和左氧氟沙星，仅一字之差，用药区别在哪？

2022-04-19

cqlidoudou (审核中...)

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#左氧氟沙星#

Clin Infect Dis：大剂量利福平联合或不联合左氧氟沙星与标准治疗儿童结核性脑膜炎的随机临床试验

2022-04-08

cqlidoudou (审核中...)

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#左氧氟沙星#

关于左氧氟沙星，你至少需要知道这5点！

2021-12-20

cqlidoudou (审核中...)

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#左氧氟沙星#

BMC Infect Dis：治疗幽门螺杆菌感染，多西环素VS.左氧氟沙星的疗效

2021-07-27

智慧医人 (审核中...)

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#左氧氟沙星#

左氧氟沙星注射剂严重不良反应，9个案例一定要牢记

2020-01-21

cqlidoudou (审核中...)

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#左氧氟沙星#

治疗幽门螺杆菌感染左氧氟沙星和阿莫西林能否联用？

2019-12-07

cqlidoudou (审核中...)

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#左氧氟沙星#

Lancet oncol：骨髓瘤患者预防性应用左氧氟沙星可降低发热和死亡率

2019-10-26

cqlidoudou (审核中...)

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#左氧氟沙星#

左氧氟沙星注射剂的严重不良反应 9个案例提醒你一定要牢记

2019-07-13

cqlidoudou (审核中...)

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#左氧氟沙星#

标准三联疗法与左氧氟沙星替代疗法治疗幽门螺杆菌感染的疗效比较

2018-10-25

cqlidoudou (审核中...)

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#左氧氟沙星#

JAMA：左氧氟沙星用于可预防儿童急性白血病强化化疗后细菌血症

2018-09-14

cqlidoudou (审核中...)

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#左氧氟沙星#

J Hazard Mater：氧化石墨烯促进左氧氟沙星和环丙沙星在饱和和不饱和多孔介质中的转运

2018-02-01

cqlidoudou (审核中...)

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#左氧氟沙星#

如果药物也会说话，听听左氧氟沙星的“烦恼”

2018-01-08

cqlidoudou (审核中...)

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#左氧氟沙星#

Intern Med J：难治性幽门螺杆菌感染：基于左氧氟沙星的三联治疗可委以重任

2017-07-26

cqlidoudou (审核中...)

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#左氧氟沙星#

Am J Gastroenterol：质子泵抑制剂-铋剂-四环素-左氧氟沙星四联疗法可有效治疗幽门螺杆菌复发感染

2017-07-23

cqlidoudou (审核中...)

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#左氧氟沙星#

警惕左氧氟沙星注射剂的严重不良反应

2017-07-22

hb2008ye (审核中...)

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#左氧氟沙星#

「警惕」左氧氟沙星注射剂的严重不良反应！

2017-03-22

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