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Sci Transl Med:粘合眼睛伤口的胶水

2017-12-11 药明康德 学术经纬

眼球壁(角膜或巩膜)出现穿透性创伤时会导致眼压迅速下降,如果不迅速治疗可能导致视网膜脱落和永久性的失明。目前对这种类型创伤的标准治疗方法是将伤口缝合起来,但是缝合眼球的技术不但非常耗时,需要特别训练和仪器,而且可能导致患者眼球不适,搓眼可能引起眼球磨损和发炎。

眼球壁(角膜或巩膜)出现穿透性创伤时会导致眼压迅速下降,如果不迅速治疗可能导致视网膜脱落和永久性的失明。目前对这种类型创伤的标准治疗方法是将伤口缝合起来,但是缝合眼球的技术不但非常耗时,需要特别训练和仪器,而且可能导致患者眼球不适,搓眼可能引起眼球磨损和发炎。

近日,南加州大学 (University of Southern California) 的研究人员开发出一种温度控制的水凝胶胶水。在低温时这种胶水呈液态,它可以被注射到眼球伤口附近,当水凝胶被体温加热后,它会凝结固化,从而达到粘合伤口的作用。凝固的胶水可以通过接触凉水被化开并且清除,不会导致任何损伤。在眼球创伤的兔子模型中,这种胶水非常容易使用,而且在显着提高伤口愈合的同时没有表现出神经毒性,视网膜组织降解和慢性炎症反应。这项研究表明这种温敏胶水可能成为暂时粘合眼球手术切口或者创伤伤口的重要选择。

相关研究成果发表在国际著名杂志《Science Translational Medicine》上。

原始出处:

Niki Bayat,et al.,A reversible thermoresponsive sealant for temporary closure of ocular trauma.Sci Transl Med.06 Dec 2017:Vol. 9, Issue 419, eaan3879.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2067296, encodeId=facf206e29675, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Mar 24 04:53:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270292, encodeId=94d62e029282, content=不错.挺好的!越来越先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Dec 18 08:56:08 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656926, encodeId=b78916569263f, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Sep 22 01:53:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608337, encodeId=3da0160833e29, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 13 04:53:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268648, encodeId=5f5726864819, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Dec 11 17:12:24 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-18 半夏微凉

    不错.挺好的!越来越先进

    0

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    2018-09-22 bsmagic9140
  4. [GetPortalCommentsPageByObjectIdResponse(id=2067296, encodeId=facf206e29675, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Mar 24 04:53:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270292, encodeId=94d62e029282, content=不错.挺好的!越来越先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Dec 18 08:56:08 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656926, encodeId=b78916569263f, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Sep 22 01:53:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608337, encodeId=3da0160833e29, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 13 04:53:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268648, encodeId=5f5726864819, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Dec 11 17:12:24 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
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    2017-12-11 天涯183

    非常好的文章.学习了

    0

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