Baidu
map

Circulation:先天性心脏病患者痴呆风险!

2018-02-14 xing.T MedSci原创

由此可见,与一般人群相比,CHD与老年痴呆症风险增加,尤其是早发性痴呆。进一步了解CHD患者痴呆风险是未来研究的一个潜在目标。

越来越多的先天性心脏病(CHD)儿童可以存活到成年,CHD与痴呆的危险因素有关。近日,心血管领域权威杂志Circulation上发表了一篇研究文章,研究人员比较了CHD成人与普通人群发生痴呆的风险。

在这项队列研究中,研究人员使用了涵盖所有丹麦医院的医疗登记中心和病例记录以确定在1963年至2012年期间诊断为CHD的成人。这些CHD患者从1981年1月1日、30岁或第一次CHD登记日随访至医院诊断痴呆、死亡、移民或研究结束(2012年12月31日)。对于每一个CHD患者,研究人员利用丹麦的民事登记系统匹配了性别和出生年份的10名普通人群。研究人员计算了痴呆的累积发生率和风险比(HRs),并根据性别和出生年份进行调整。

在10632名成人CHD患者中,80岁以上老年人痴呆累计发病率为4%(46%为男性)。CHD与一般人群相比,整体HR为1.6(95%可信区间[CI]为1.3-2.0)。没有心外缺陷的CHD患者HR为1.4(95%CI为1.1-1.8)。轻度至中度成年CHD患者的HR为1.5(95%CI为1.1-2.0),而包括单心室在内的严重CHD患者HR为2.0(95%CI为1.2-3.3)。早发性(<65岁)痴呆的HR为2.6(95%CI为1.8-3.8),而迟发性痴呆的HR为1.3(95%CI为1-1.8)。

由此可见,与一般人群相比,CHD与老年痴呆症风险增加,尤其是早发性痴呆。进一步了解CHD患者痴呆风险是未来研究的一个潜在目标。

原始出处:

Carina N. Bagge,et al. Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study.Circulation. 2018. https://doi.org/10.1161/CIRCULATIONAHA.117.029686

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1316696, encodeId=d5d5131669675, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369347, encodeId=8c85136934eba, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287925, encodeId=400128e925c2, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 14 16:02:32 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287919, encodeId=f7f728e919c0, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Wed Feb 14 15:13:36 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1316696, encodeId=d5d5131669675, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369347, encodeId=8c85136934eba, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287925, encodeId=400128e925c2, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 14 16:02:32 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287919, encodeId=f7f728e919c0, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Wed Feb 14 15:13:36 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-16 huirong
  3. [GetPortalCommentsPageByObjectIdResponse(id=1316696, encodeId=d5d5131669675, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369347, encodeId=8c85136934eba, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287925, encodeId=400128e925c2, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 14 16:02:32 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287919, encodeId=f7f728e919c0, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Wed Feb 14 15:13:36 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1316696, encodeId=d5d5131669675, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369347, encodeId=8c85136934eba, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Fri Feb 16 06:02:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287925, encodeId=400128e925c2, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 14 16:02:32 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287919, encodeId=f7f728e919c0, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Wed Feb 14 15:13:36 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 wqkm

    ^_^^_^^_^

    0

相关资讯

Int J Cardiol:成年先天性心脏病患者心源性猝死的发生率及临床特点!

由此可见,成年CHD患者发生SCD的风险仍然较高,尤其是存在复杂的基础性缺陷患者。中等到高风险病变包括艾森门格综合征、完全性大动脉转位(心房调转术或先天性矫正)和Fontan循环。

JAHA:循环成纤维细胞生长因子21在2型糖尿病患者冠心病初级预防中的作用!

研究人员首次证明了血清FGF21水平是冠心病发病的一个独立预测因子,在初级预防中其可以作为鉴别2型糖尿病患者冠心病风险升高个体的有用的生物标志物。

SCI REP:非酒精性脂肪肝与冠状动脉钙化有何关系?

由此可见,该研究的发现进一步证实了NAFLD与CAC之间存在的关联,特别是在亚洲人群中。

Heart:环境温度增加冠状动脉心脏病和卒中住院治疗!

由此可见,环境温度,特别是在适度的温度范围内,可能是心血管疾病相关住院治疗的一个重要的危险因素。

Int J Cardiol:先天性心脏病患儿感染性心内膜炎的危险因素分析!

由此可见,该研究表明CHD病变患者IE的风险明显有所不同。侵入性心脏手术,而不是牙科手术,与CHD儿童的IE显著相关。

Heart:先天性心脏病相关肺动脉高压患者皮下曲前列环素疗效分析!

由此可见,皮下注射曲前列环素治疗总体安全有效,疗效至少持续12个月,可用于冠心病相关PAH患者的治疗。

Baidu
map
Baidu
map
Baidu
map