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Lancet子刊:20万人数据——远超遗传,这3种疾病明显增加痴呆症风险!

2022-07-09 MedSci原创 MedSci原创

心脏代谢疾病和遗传因素与痴呆风险的增加有关。

心脏代谢疾病和遗传因素与痴呆风险的增加有关。然而,痴呆和心脏代谢性多发病之间的关系尚不清楚。为此,来自牛津的学者调查了心脏代谢性多发病是否会增加痴呆症的风险,并检查了相关的大脑结构变化,结果发表在The Lancet Healthy Longevity杂志上。

研究人员调查了203038名欧洲血统的UKBIOBANK参与者的健康和遗传数据,他们在基线评估时年龄在60岁以上,没有痴呆症,并随访到2021年3月31日。同时获取了12236名参与者的嵌套成像子样本的脑结构数据。为每个参与者计算了由中风、糖尿病心肌梗死组成的心脏代谢性多发病指数(各占1分),以及痴呆症的多基因风险评分(有低、中、高风险组)。主要的结果衡量标准是全因性痴呆的发生和大脑结构指标。

结果显示,与高心脏代谢性疾病相关的痴呆风险是遗传风险的3倍(HR= 5.55,95% CI 3.39-9.08,P<0.0001;和1.68,1.53-1.84,P<0.0001)。同时与具有低遗传风险和没有心脏代谢性疾病的参与者相比,多发病指数≥2的参与者患痴呆症的风险明显增加(HR=5.74,95% CI 4.26-7.74,p<0.0001)。

最重要的是,该研究发现心脏代谢性疾病和多基因风险之间没有相互作用。心脏代谢性多发病与更广泛、更普遍的大脑结构变化独立相关,包括较低的海马体积和总灰质体积。

综上,与遗传风险相比,心脏代谢性疾病与痴呆和广泛的脑成像差异的风险独立相关,且影响程度高于遗传风险带来的影响。

 

参考文献:

Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. The Lancet Healthy Longevity. Jun 2022. DOI:https://doi.org/10.1016/S2666-7568(22)00117-9

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1831605, encodeId=7f501831605f9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Dec 20 07:41:47 CST 2022, time=2022-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836312, encodeId=a3461836312fd, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Mon Nov 07 07:41:47 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231513, encodeId=86af123151309, content=好的,学习了,以后有机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09fe5428602, createdName=zhangzhiyingying, createdTime=Sat Jul 09 18:05:15 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244042, encodeId=1777124404270, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247134, encodeId=5ad0124e1344b, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=)]
    2022-12-20 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1831605, encodeId=7f501831605f9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Dec 20 07:41:47 CST 2022, time=2022-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836312, encodeId=a3461836312fd, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Mon Nov 07 07:41:47 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231513, encodeId=86af123151309, content=好的,学习了,以后有机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09fe5428602, createdName=zhangzhiyingying, createdTime=Sat Jul 09 18:05:15 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244042, encodeId=1777124404270, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247134, encodeId=5ad0124e1344b, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=)]
    2022-11-07 Boyinsh
  3. [GetPortalCommentsPageByObjectIdResponse(id=1831605, encodeId=7f501831605f9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Dec 20 07:41:47 CST 2022, time=2022-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836312, encodeId=a3461836312fd, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Mon Nov 07 07:41:47 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231513, encodeId=86af123151309, content=好的,学习了,以后有机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09fe5428602, createdName=zhangzhiyingying, createdTime=Sat Jul 09 18:05:15 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244042, encodeId=1777124404270, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247134, encodeId=5ad0124e1344b, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=)]
    2022-07-09 zhangzhiyingying

    好的,学习了,以后有机会

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1831605, encodeId=7f501831605f9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Dec 20 07:41:47 CST 2022, time=2022-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836312, encodeId=a3461836312fd, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Mon Nov 07 07:41:47 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231513, encodeId=86af123151309, content=好的,学习了,以后有机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09fe5428602, createdName=zhangzhiyingying, createdTime=Sat Jul 09 18:05:15 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244042, encodeId=1777124404270, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247134, encodeId=5ad0124e1344b, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=)]
    2022-07-09 younei

    lancet上果然牛,感谢梅斯更新及时

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1831605, encodeId=7f501831605f9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Dec 20 07:41:47 CST 2022, time=2022-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836312, encodeId=a3461836312fd, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Mon Nov 07 07:41:47 CST 2022, time=2022-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1231513, encodeId=86af123151309, content=好的,学习了,以后有机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09fe5428602, createdName=zhangzhiyingying, createdTime=Sat Jul 09 18:05:15 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244042, encodeId=1777124404270, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247134, encodeId=5ad0124e1344b, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Jul 09 14:41:47 CST 2022, time=2022-07-09, status=1, ipAttribution=)]
    2022-07-09 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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