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Neurology:血清神经丝蛋白是高敏感的脑震荡生物标记物

2017-04-07 zhangfan MedSci原创

血清神经丝蛋白是高敏感的脑震荡生物标记物

研究人员近日就血清轴突神经丝蛋白(NFL)能否作为脑震荡的敏感生物标记物进行了研究。

研究包括2项内容:首先,研究人员对14瑞典业余拳击运动员,在完赛7 - 10天以及休息3个月后,进行了血液生物标志物检测;之后,对35瑞典职业冰球运动员,在比赛后第1,12,36和114小时,进行了血液生物标志物检测。14名健康的非运动和12名运动员作为对照组。利用超灵敏的单分子阵列技术测定血清NFL水平。

研究发现,相比于赛后3个月以及对照组,赛后7-10天拳击运动员血清NFL浓度大幅上升(p = 0.0007和 p < 0.0001),血清NFL在休息了3个月后下降但也高于对照组(p < 0.0001),在比赛中受到多次头部重击(>15)的选手血清NFL水平要高于其他选手(p = 0.0023)。在冰球运动员中进行的测试与拳击运动员相同。血清NFL还可以区分患者是受到的短暂的脑震荡冲击还是长期的脑震荡冲击。

该研究表明,血清神经丝蛋白是高敏感的脑震荡生物标记物。

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    2017-04-25 yinhl1978
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    2018-03-07 wjywjy
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